Vitamin K Mechanism of action【USMLE Biochemistry】


Published on Mar 12, 2019
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This video is about vitamin K for USMLE prep.
Do you know why coagulation factors need vitamin K?
Why do they need carboxylation?
Here is the answer.

(Reference)

1. Bruce Furie, Beth A. Bouchard and Barbara C. Furie
Vitamin K-Dependent Biosynthesis of γ-Carboxyglutamic Acid
Blood 1999 93:1798-1808

2. Berkner KL.
Vitamin K-dependent carboxylation.
Vitam Horm. 2008;78:131-56.

3. Mark A. Rishavy* and Kathleen L. Berkner
Vitamin K Oxygenation, Glutamate Carboxylation, and Processivity: Defining the Three Critical Facets of Catalysis by the Vitamin K–Dependent Carboxylase
Adv Nutr. 2012 Mar; 3(2): 135–148. doi: 10.3945/an.111.001719

(Opening Movie)
light house; Pixabay pixabay.com
music; Seashore Synthetic. OtoLogic. http://otologic.jp

(Picture)
pirates (scurvy),
gastrointestinal system(malabsorption)
pills(antibiotics)
newborn
mather taking pills ; Pixabay pixabay.com

Bleeding time: Medline Surgicutt Bleeding Time Devices by Accriva Diagnostics. medline.com

connective tissue: Anatomy Language & Histology - WordPress.com


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